White House cancels tours, citing sequester

?

By Shawna Thomas and Kristen Welker, NBC News

The White House is canceling tours of the president's famous abode starting next week, saying the budget cuts that went into effect last week are to blame.?

A phone recording on the call line for White House visitors informs callers that White House tours will be canceled, starting this weekend.?

"Due to staffing reductions resulting from sequestration, we regret to inform you that White House tours will be canceled effective Saturday March 9th, 2013 until further notice," the recording says. "Unfortunately, we will not be able to reschedule affected tours. ?We very much regret having to take this action particularly during the popular spring touring season."?

The reason for the cancellations, an official with the Secret Service told NBC News, is?because?the Uniformed Division Officers normally tasked with securing the tours will be reassigned to other security posts at the White House. The move will reduce overtime costs and may reduce the number of furloughs the Secret Service could potentially face, according to the official.?

It is unclear how many Uniform Division Officers will be impacted by the sequester. The Office of Management and Budget calculated that the Secret Service may need to cut as much as $84 million from its budget due to the cuts.

Though the White House made the ultimate decision to suspend tours, their conclusion was based on staffing decisions the Secret Service?has been?forced to make, according to a White House official.

The move, which Republicans paint as a publicity stunt, prompted at least one proposed legislative fix from a GOP congressman Tuesday.?

In an amendment to a GOP stopgap budget bill headed to the floor later this week, Rep. Louis Gohmert, R-Texas, suggested that no funds from the bill be used "to transport the President to or from a golf course until public tours of the White House resume."

House Administration Committee Chair Candice Miller, R-Mich., said in a statement that the canceled tours are "wrong" and invited tourists to Washington D.C. to tour the Capitol instead.?

"I believe closing the doors of the White House to the American people is wrong," she wrote. "I want to let those Americans planning a trip to Washington, D.C. know that the Capitol will remain open and encourage those wishing to visit to contact their member of Congress or the Capitol Visitors Center to schedule a tour."

As required by law, President Barack Obama ordered the automatic cuts into effect last Friday night. The broad budget reductions came after Congress and the administration failed to reach an agreement to avert the sequester.?

NBC's Carrie Dann contributed?

This story was originally published on Tue Mar 5, 2013 3:25 PM EST

Source: http://firstread.nbcnews.com/_news/2013/03/05/17197602-white-house-cancels-tours-citing-sequester?lite

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Arkansas lawmakers approve toughest abortion limits in nation

AP Photo/Danny Johnston

Arkansas Gov. Mike Beebe is interviewed at the Arkansas state Capitol in Little Rock, Ark., on Monday, March 4, 2013, after vetoing legislation that would have banned abortions 12 weeks into a pregnancy.

By Miranda Leitsinger, Staff Writer, NBC News

Arkansas' House of Representatives on Wednesday rejected the governor's veto of a controversial bill that would make most abortions illegal after 12 weeks of pregnancy, thus setting up the most restrictive ban on the procedure nationwide.

The House vote of 56-33 followed Senate approval on Tuesday to override Gov. Mike Beebe?s veto of SB 134, or the Arkansas Human Heartbeat Protection Act, which enforces a ban on abortion earlier in pregnancy than any other state now does.

Moments before the vote, Rep. Ann V. Clemmer, who said she was pro-life, told fellow representatives they should give the right to be born to babies in Arkansas and that life was ?to be protected not only by a third party but from the mother herself.?

The state already has one of the most restrictive abortion laws in the U.S. after the Republican-led Legislature last week overrode Beebe's veto of a similar bill that set the legal abortion threshold at 20 weeks' gestation ? two to four weeks earlier than most states.

That law took effect immediately but the new measure won't until 90 days after the Legislature adjourns in mid-May.

The American Civil Liberties Union said the new law imposed the most severe ban in the country and the strictest limit on the procedure since the U.S. territory of Guam tried to ban all abortions in 1990. The group ?will challenge this dangerous and unconstitutional law in court,??the group?s executive director, Anthony D. Romero, said in a statement.

Talcott Camp, deputy director of the ACLU?s Reproductive Freedom Project, said before the vote that it was an ?unconstitutional and grotesque invasion? into private medical decisions.

?It?s a power grab by politicians. They are just looking to intrude on and take away a decision that is really for a woman and her family and her doctor, and that is true as a constitutional matter. It?s also true as a moral matter and as a matter of public health and just what?s right,? she said. ?This is not a decision for politicians to make.?

The Supreme Court has said viability of a fetus has to be left up to doctors, Camp said, adding that it was unconstitutional for state legislatures to set a number of weeks for when abortion could be banned.

Beebe, a Democrat, said in his veto letter on Monday that the ?adoption of blatantly unconstitutional laws can be very costly to the taxpayers of our state,? and that Arkansas? ?interest in protecting fetal life is simply not strong enough at such point to trump the constitutional rights of the mother.?

Matt DeCample, a spokesman for Beebe, said Wednesday after the vote: "The governor made his case very plainly in his veto letter, laid out the reasons why we feel the bill?s unconstitutional, and now it looks like it will be up to the courts to make the final decision.?

Women who want to end a pregnancy face a growing number of roadblocks in many parts of the country 40 years after the U.S. Supreme Court struck down many state restrictions on abortion with Roe v. Wade.

Last year, 19 states enacted a total of 43 provisions limiting access to abortion, according to the Guttmacher Institute, a non-profit that aims to advance reproductive health and abortion rights. While that was half the number that went into effect the previous year, it was the second-highest number since 1985.

Related:
Arkansas governor vetoes ban on abortions after 12 weeks
40 years after Roe v. Wade, more states restricting abortion

NBC News? Tracy Connor contributed to this report.

Source: http://usnews.nbcnews.com/_news/2013/03/06/17212230-arkansas-lawmakers-approve-toughest-abortion-limits-in-nation?lite

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Suitable Ulcerative Colitis Diet - Ayushveda.com

Ulcerative Colitis is one of the inflammatory bowel diseases during which the colon or the large intestine is affected with inflammation. The condition is categorized with Crohn?s Diseases where the problem exists for long. The condition causes open sores and flare-ups at the rectal point.

Ulcerative colitis is a painful situation accompanied with the other problems like diarrhoea with bleeding problem, ulcer, cramps and bloating. Reason behind the condition may be different from the dietary factors but particular food item can trigger the condition.

It is always advised to avoid the foods which exacerbate the condition of Ulcerative colitis and reason flare-ups. Here is the most advised diet plan which helps to relax the painful condition of Ulcerative colitis.

Diet Tips For?Ulcerative Colitis

Moderation in Fiber Intake

Fiber rich diets are meant to be the best for digestion but with Ulcerative colitis, high fiber diet can cause flare-ups, constipation and diarrhoea.

Source:?http://www.prediabetics.org/493/fiber-rich-diets-revealed-to-help-keep-type-2-diabetes-away/

So, it is advised to take fiber in limited ways. Instead of raw fruits and vegetables intake it is better to have them boiled or steamed. It is also applied with the legumes and whole grains ingestion.

Reduce Dairy Products Intake

The milk sugar presented in the dairy products normally aggravates the condition of Ulcerative colitis. Most of patients with the condition get intolerance from lactose which causes fear of inflammation and flare-ups with increased gastric problems.

But it is quite unacceptable to fully eliminate the dairy products from daily diet as it is the best way to add calcium and protein. To avoid the worst result, it is suggested to add enzyme products helpful in breaking down lactose for better condition.

Increased Intake of Fluid

Drinking plenty of water can relax the ulcerative colitis condition. Adequate amount of fluid intake lessens the chance of constipation and indigestion. Whole body gets detoxified with the help of water.

Fresh juices with no harmful effects on the condition are also suggested for relaxed situation. Carbonated beverages and other hard drinks should be avoided as the very drinks exacerbate the ulcerative colitis condition by flare-ups and constipation.

Ingestion of Multi-Vitamins Supplements

Due to limited sources of nutritional diet during Ulcerative colitis, the body gets weak. With little nutrition and interrupted ability of body parts, the function of nutrition absorption is also slowed down.

It is advised to consult a renowned dietician or doctor to know about the best multi-vitamins supplements along with useful minerals suitable for the condition to provide a better balance of nutrition in body in spite of limited diet ingestion.

Reduction of Caffeine Intake

Caffeinated drinks such as tea and coffee can increase the bowel movement and hence cause inflammation and painful flare-ups. In Ulcerative colitis condition, it is advised to limit or eliminate the intake of these beverages for relaxed sores and inflammation around rectum.

Here are some specific diet ideas to get a stable condition of Ulcerative colitis. With a slight moderation in diet and eliminating problem foods from daily routine can miraculously show enhanced healthy position even in the very inflammatory bowel disease.

Photo Credit:?https://www.healthtap.com/topics/define-ischemic-colitis

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Source: http://www.ayushveda.com/magazine/suitable-ulcerative-colitis-diet/

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Dealersocket Issues - DealerRefresh Automotive Technology Forums

Need some help,

We have a multi-franchise group with Car, RV and Boat dealerships. Until a recent upgrade Dealersocket was able to integrate with my RV and Boat stores. Now it doesn't. The root of the issue is they can't turn off Vin explosion.

1. We cannot enter trades of any motorcycle, RV, or boat
2. Our inventory of RVS & Boats is not searchable
3. Make and model of RV is not displayed. Vin explosion removes data that comes from our feed
4. No marketing can be done based on make or model of RVs or Boats
5. Documents cannot be printed with make and model of RV or Boats
6. Sales events will not display make and model of RV or Boats
7. Can't enter any trade other than a car!

Does anyone know of a CRM you can use for RV's, Boats, & motorcycles? Any help would greatly appreciated! I'm at the end of my rope!

Source: http://forum.dealerrefresh.com/f5/dealersocket-issues-3155.html

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Calif. woman dies after nurse refuses to do CPR

BAKERSFIELD, Calif. (AP) ? Police on Monday were investigating whether there was any criminal wrongdoing in the handling of a health emergency at an independent living facility where a woman died after a nurse refused to provide CPR.

The facility, Glenwood Gardens, defended its nurse, saying she had followed policy in dealing with the 87-year-old woman who fainted in a dining room.

A police dispatcher who fielded the 911 call was told the woman had a heart problem and was barely breathing.

Police immediately routed the call to the Bakersfield Fire Department, where a dispatcher pleaded with a nurse at the facility to perform CPR on the woman.

The nurse refused, saying one of the home's policies prevented her from doing CPR, according to an audio recording of the call.

Michaela Beard, a spokeswoman for Bakersfield police, said she couldn't provide any further information because the investigation was ongoing.

An unidentified woman made the Feb. 26 call, and asked for paramedics to be sent to help the woman. Later, a woman who identified herself as a nurse got on the phone and told dispatcher Tracey Halvorson she was not permitted to do CPR on the woman.

Halvorson urged the nurse to start CPR, warning the consequences could be dire if no one tried to revive the woman, who had been laid out on the floor on her instructions.

"I understand if your boss is telling you, you can't do it," the dispatcher said. "But ... as a human being ... you know, is there anybody that's willing to help this lady and not let her die?"

"Not at this time," the nurse answered.

During the 7-minute, 16-second call, Halvorson assured the nurse that Glenwood couldn't be sued if anything went wrong in attempts to resuscitate the resident, saying the local emergency medical system "takes the liability for this call," the transcript states.

Later in the call, Halvorson asks, "Is there a gardener? Any staff, anyone who doesn't work for you? Anywhere? Can we flag someone down in the street and get them to help this lady? Can we flag a stranger down? I bet a stranger would help her."

Halvorson is an experienced dispatcher and has worked for the county center for at least a decade, Kern County Fire Department Deputy Chief Michael Miller said.

She followed procedures until she ran out of options when the caller refused to perform CPR or identify anyone else who could, Miller said.

"It's not uncommon to have someone refuse to provide CPR if they physically can't do it, or they're so upset they just can't function," Miller said. "What made this one unique was the way the conversation on the phone went. It was just very frustrating to anyone listening to it, like, why wasn't anyone helping this poor woman, since CPR today is much simpler than it was in the past?"

Firefighters and ambulance personnel arrived at the facility seven minutes after the call came in, Miller said. The county does not know who made the call, he added.

The woman had no pulse and wasn't breathing when fire crews reached her, fire Battalion Chief Anthony Galagaza said.

They started CPR and loaded her onto a gurney, and the woman was later declared dead at Mercy Southwest Hospital.

The executive director of Glenwood Gardens, Jeffrey Toomer, defended the nurse, saying she follow the facility's policy.

"In the event of a health emergency at this independent living community our practice is to immediately call emergency medical personnel for assistance and to wait with the individual needing attention until such personnel arrives," Toomer said in a written statement. "That is the protocol we followed."

Toomer offered condolences to the woman's family and said a thorough internal review of the incident would be conducted.

He told KGET-TV that residents of the facility are informed of the policy and agree to it when they move in. He said the policy does not apply at the adjacent assisted living and skilled nursing facilities.

A call to the facility by The Associated Press seeking more information was not immediately returned.

Annette Pellens, a registered nurse who owns an assisted living facility across the street from Glenwood, said such an incident puts caregivers in a difficult ethical position.

"In that situation, you summon EMS and you do what's the right thing to do," Pellens said.

___

Burke reported from San Francisco.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-04-No%20CPR-Woman%20Dies/id-42ba176cde4a4564b3f5e88464b58149

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Human Y chromosome much older than previously thought

Mar. 4, 2013 ? The discovery and UA analysis of an extremely rare African American Y chromosome pushes back the time of the most recent common ancestor for the Y chromosome lineage tree to 338,000 years ago. This time predates the age of the oldest known anatomically modern human fossils.

UA geneticists have discovered the oldest known genetic branch of the human Y chromosome -- the hereditary factor determining male sex.

The new divergent lineage, which was found in an individual who submitted his DNA to Family Tree DNA, a company specializing in DNA analysis to trace family roots, branched from the Y chromosome tree before the first appearance of anatomically modern humans in the fossil record.

The results are published in the American Journal of Human Genetics.

"Our analysis indicates this lineage diverged from previously known Y chromosomes about 338,000 ago, a time when anatomically modern humans had not yet evolved," said Michael Hammer, an associate professor in the University of Arizona's department of ecology and evolutionary biology and a research scientist at the UA's Arizona Research Labs. "This pushes back the time the last common Y chromosome ancestor lived by almost 70 percent."

Unlike the other human chromosomes, the majority of the Y chromosome does not exchange genetic material with other chromosomes, which makes it simpler to trace ancestral relationships among contemporary lineages. If two Y chromosomes carry the same mutation, it is because they share a common paternal ancestor at some point in the past. The more mutations that differ between two Y chromosomes the farther back in time the common ancestor lived.

Originally, a DNA sample obtained from an African American living in South Carolina was submitted to the National Geographic Genographic Project. When none of the genetic markers used to assign lineages to known Y chromosome groupings were found, the DNA sample was sent to Family Tree DNA for sequencing. Fernando Mendez, a postdoctoral researcher in Hammer's lab, led the effort to analyze the DNA sequence, which included more than 240,000 base pairs of the Y chromosome.

Hammer said "the most striking feature of this research is that a consumer genetic testing company identified a lineage that didn't fit anywhere on the existing Y chromosome tree, even though the tree had been constructed based on perhaps a half-million individuals or more. Nobody expected to find anything like this."

About 300,000 years ago, the time the Neanderthals are believed to have split from the ancestral human lineage. It was not until more than 100,000 years later that anatomically modern humans appear in the fossil record. They differ from the more archaic forms by a more lightly built skeleton, a smaller face tucked under a high forehead, the absence of a cranial ridge and smaller chins.

Hammer said the newly discovered Y chromosome variation is extremely rare. Through large database searches, his team eventually was able to find a similar chromosome in the Mbo, a population living in a tiny area of western Cameroon in sub-Saharan Africa.

"This was surprising because previously the most diverged branches of the Y chromosome were found in traditional hunter-gatherer populations such as Pygmies and the click-speaking KhoeSan, who are considered to be the most diverged human populations living today."

"Instead, the sample matched the Y chromosome DNA of 11 men, who all came from a very small region of western Cameroon," Hammer said. "And the sequences of those individuals are variable, so it's not like they all descended from the same grandfather."

Hammer cautions against popular concepts of "mitochondrial Eve" or "Y chromosome Adam" that suggest all of humankind descended from exactly one pair of humans that lived at a certain point in human evolution.

"There has been too much emphasis on this in the past," he said. "It is a misconception that the genealogy of a single genetic region reflects population divergence. Instead, our results suggest that there are pockets of genetically isolated communities that together preserve a great deal of human diversity."

Still, Hammer said, "It is likely that other divergent lineages will be found, whether in Africa or among African-Americans in the U.S. and that some of these may further increase the age of the Y chromosome tree."

He added: "There has been a lot of hype with people trying to trace their Y chromosome to different tribes, but this individual from South Carolina can say he did it."

The study came about by combined efforts of a private business, Family Tree DNA, the efforts of a citizen scientist, Bonnie Schrack, and the research capabilities at the UA.

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The above story is reprinted from materials provided by University of Arizona. The original article was written by Daniel Stolte.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Fernando?L. Mendez, Thomas Krahn, Bonnie Schrack, Astrid-Maria Krahn, Krishna?R. Veeramah, August?E. Woerner, Forka?Leypey?Mathew Fomine, Neil Bradman, Mark?G. Thomas, Tatiana?M. Karafet, Michael?F. Hammer. An African American Paternal Lineage Adds an Extremely Ancient Root to the Human Y Chromosome Phylogenetic Tree. The American Journal of Human Genetics, 2013; DOI: 10.1016/j.ajhg.2013.02.002

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/xT-k_1UJJ3s/130305145821.htm

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Twelve pro-army militiamen killed in Yemen - commander

ADEN (Reuters) - A suicide bomber killed at least 12 members of a pro-government militia that helped the Yemeni army to drive al Qaeda-linked Islamist militants out of southern strongholds in a U.S.-backed campaign last year, a commander said on Monday.

Nizar Jaafar said 15 other people had been wounded in the attack on an office of the Popular Committees in the town of Lawdar in the southern province of Abyan.

Residents said the force of the blast shook the center of Lawdar. No one claimed responsibility for the attack, but Islamist group Ansar al-Sharia has previously said it carried out similar bombings, often in reprisal for the tribal fighters' role in driving the militants out of their strongholds.

Yemen has been grappling with multiple challenges since a popular uprising forced President Ali Abdullah Saleh out of office in 2011 and brought Abd-Rabbu Mansour Hadi in his place.

Apart from the Islamist militant insurgency, the U.S.-allied country which is next door to the world's top oil exporter, Saudi Arabia, is fighting a separatist movement seeking to revive the Socialist state that merged with North Yemen in 1990, as well as a potential challenge from Shi'ite Muslim rebels known as Houthis in the north.

Ansar al-Sharia has carried out a campaign of suicide attacks against the Yemeni army and its militia allies after they were forced to quit cities they captured in 2011, during the turmoil that accompanied the popular protests against Saleh.

In a separate incident, a local official said that four suspected militants have escaped from a prison in Lawdar on Monday. The official gave no further details.

The United States has used unmanned drones to target the al Qaeda group in Yemen, which has planned attacks on international targets including airliners and is described by Washington as the movement's most dangerous wing.

(Reporting by Mohammed Mukhashaf; Writing by Sami Aboudi; Editing by Stephen Powell)

Source: http://news.yahoo.com/twelve-pro-army-militiamen-killed-yemen-commander-171608245.html

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Why your brain tires when exercising

Mar. 4, 2013 ? A marathon runner approaches the finishing line, but suddenly the sweaty athlete collapses to the ground. Everyone probably assumes that this is because he has expended all energy in his muscles. What few people know is that it might also be a braking mechanism in the brain which swings into effect and makes us too tired to continue. What may be occurring is what is referred to as 'central fatigue'.

"Our discovery is helping to shed light on the paradox which has long been the subject of discussion by researchers. We have always known that the neurotransmitter serotonin is released when you exercise, and indeed, it helps us to keep going. However, the answer to what role the substance plays in relation to the fact that we also feel so exhausted we have to stop has been eluding us for years. We can now see it is actually a surplus of serotonin that triggers a braking mechanism in the brain. In other words, serotonin functions as an accelerator but also as a brake when the strain becomes excessive," says Associate Professor Jean-Fran?ois Perrier from the Department of Neuroscience and Pharmacology, who has spearheaded the new research.

Help in the battle against doping

Jean-Fran?ois Perrier hopes that mapping the mechanism that prompts central fatigue will be useful in several ways. Central fatigue is a phenomenon which has been known for about 80 years; it is a sort of tiredness which, instead of affecting the muscles, hits the brain and nervous system. By conducting scientific experiments, it is possible to observe and measure that the brain sends insufficient signals to the muscles to keep going, which in turn means that we are unable to keep performing. This makes the mechanism behind central fatigue an interesting area in the battle against doping, and it is for this reason that Anti Doping Danmark has also helped fund the group's research.

"In combating the use of doping, it is crucial to identify which methods athletes can use to prevent central fatigue and thereby continue to perform beyond what is naturally possible. And the best way of doing so is to understand the underlying mechanism," says Jean-Fran?ois Perrier.

Developing better drugs

The brain communicates with our muscles using so-called motoneurons (see fact box). In several diseases, motoneurons are hyperactive. This is true, for example, of people suffering from spasticity and cerebral palsy, who are unable to control their movements. Jean-Fran?ois Perrier therefore hopes that, in the long term, this new knowledge can also be used to help develop drugs against these symptoms and to find out more about the effects of antidepressants.

"This new discovery brings us a step closer to finding ways of controlling serotonin. In other words, whether it will have an activating effect or trigger central fatigue. It is all about selectively activating the receptors which serotonin attaches to," explains Jean-Fran?ois Perrier.

"For selective serotonin re-uptake inhibitor (SSRI) drugs which are used as antidepressants, we can possibly help explain why those who take the drugs often feel more tired and also become slightly clumsier than other people. What we now know can help us develop better drugs," concludes Jean-Fran?ois Perrier.

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The above story is reprinted from materials provided by University of Copenhagen, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Florence Cotel, Richard Exley, Stephanie J. Cragg, and Jean-Fran?ois Perrier. Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation. PNAS, 2013 DOI: 10.1073/pnas.1216150110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/N9fHblUSv9M/130304151805.htm

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Star Tribune poll: Most Minnesotans want tax hike only on wealthy (Star Tribune)

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Scientists identify 'clean-up' snafu that kills brain cells in Parkinson's disease

Mar. 3, 2013 ? Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells. The study, which published online today in the journal Nature Neuroscience, could also open up treatment possibilities for both familial Parkinson's and the more common form of Parkinson's that is not inherited.

Parkinson's disease is a gradually progressing disorder of the nervous system that causes stiffness or slowing of movement. According to the Parkinson's Disease Foundation, as many as one million Americans are living with the disease.

The most common mutations responsible for the familial form of Parkinson's disease affect a gene called leucine-rich repeat kinase-2 (LRRK2). The mutations cause the LRRK2 gene to code for abnormal versions of the LRRK2 protein. But it hasn't been clear how LRRK2 mutations lead to the defining microscopic sign of Parkinson's: the formation of abnormal protein aggregates inside dopamine-producing nerve cells of the brain.

"Our study found that abnormal forms of LRRK2 protein disrupt an important garbage-disposal process in cells that normally digests and recycles unwanted proteins including one called alpha-synuclein -- the main component of those protein aggregates that gunk up nerve cells in Parkinson's patients," said study leader Ana Maria Cuervo, M.D., Ph.D., professor of developmental and molecular biology, of anatomy and structural biology, and of medicine and the Robert and Renee Belfer Chair for the Study of Neurodegenerative Diseases at Einstein.

The name for the disrupted disposal process is chaperone-mediated autophagy (the word "autophagy" literally means "self-eating"). It involves specialized molecules that "guide" old and damaged proteins to enzyme-filled structures called lysosomes; there the proteins are digested into amino acids, which are then recycled within the cell.

"We showed that when LRRK2 inhibits chaperone-mediated autophagy, alpha-synuclein doesn't get broken down and instead accumulates to toxic levels in nerve cells," said Dr. Cuervo.

The study involved mouse neurons in tissue culture from four different animal models, neurons from the brains of patients with Parkinson's with LRRK2 mutations, and neurons derived from the skin cells of Parkinson's patients via induced pluripotent stem (iPS) cell technology. All the lines of research confirmed the researchers' discovery.

"We're now looking at ways to enhance the activity of this recycling system to see if we can prevent or delay neuronal death and disease," said Dr. Cuervo. "We've started to analyze some chemical compounds that look very promising."

Dr. Cuervo hopes that such treatments could help patients with familial as well as nonfamilial Parkinson's -- the predominant form of the disease that also involves the buildup of alpha-synuclein.

Dr. Cuervo is credited with discovering chaperone-mediated autophagy. She has published extensively on autophagy and its role in numerous diseases, such as Huntington's disease, and its role in age-related conditions, including organ decline and weakened immunity. Dr. Cuervo is co-director of Einstein's Institute of Aging Research.

The paper is titled "Interplay of LRRK2 with chaperone-mediated autophagy." In addition to Dr. Cuervo, other Einstein contributors include Samantha J. Orenstein, a graduate student who performed most of this study as part of her Ph.D. thesis; Inmaculada Tasset, Ph.D.; Esperanza Arias, Ph.D.; and Hiroshi Koga, Ph.D., all members of Dr. Cuervo's group. Additional co-authors are: Sheng-Hang Kuo Ph.D., David Sulzer Ph.D., Etty Cortes, M.D., and Lawrence S. Honig, M.D. (Columbia University, NY); William Dauer, M.D., (University of Michigan, Ann Arbor, MI); Irene Fernandez-Carasa and Antonella Consiglio, Ph.D., (University of Barcelona, Barcelona Spain); and Angel Raya, M.D., Ph.D., (Institucio Catalana de Recerca I Estudies Avancas, Barcelona, Spain).

This work was supported by grants from the National Institute on Aging (AG031782 and AG08702), the National Institute of Neurological Disorders and Stroke Udall Center of Excellence both part of the National Institutes of Health; The Rainwaters Foundation, The Beatrice and Roy Backus Foundation, JPB Foundation; Parkinson's Disease Foundation; Fondazione Guido Berlucchi; Centers for Networked Biomedical Research; Ministry of Economy and Competitiveness; a Hirschl/Weill-Caulier Career Scientist Award; and a gift from Robert and Renee Belfer.

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The above story is reprinted from materials provided by Albert Einstein College of Medicine of Yeshiva University.

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---

Journal Reference:

1. Samantha J Orenstein, Sheng-Hang Kuo, Inmaculada Tasset, Esperanza Arias, Hiroshi Koga, Irene Fernandez-Carasa, Etty Cortes, Lawrence S Honig, William Dauer, Antonella Consiglio, Angel Raya, David Sulzer and Ana Maria Cuervo. Interplay of LRRK2 with chaperone-mediated autophagy. Nature Neuroscience, 03 March 2013 DOI: 10.1038/nn.3350

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/XSJZ5h3-ruw/130303154850.htm

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Bud Selig calls for tougher drug penalties

MLB Commissioner Bud Selig speask with reporters at a press conference regarding drug testing in major league baseball during a spring training baseball game at Salt River Fields near Scottsdale, Ariz., Saturday, March 2, 2013. He said he wants tougher penalties for major league players who violate the sport's drug agreement. (AP Photo/The Arizona Republic, Cheryl Evans) MARICOPA COUNTY OUT; MAGS OUT; NO SALES

MLB Commissioner Bud Selig speask with reporters at a press conference regarding drug testing in major league baseball during a spring training baseball game at Salt River Fields near Scottsdale, Ariz., Saturday, March 2, 2013. He said he wants tougher penalties for major league players who violate the sport's drug agreement. (AP Photo/The Arizona Republic, Cheryl Evans) MARICOPA COUNTY OUT; MAGS OUT; NO SALES

MLB Commissioner Bud Selig speask with reporters at a press conference regarding drug testing in major league baseball during a spring training baseball game at Salt River Fields near Scottsdale, Ariz., Saturday, March 2, 2013. He said he wants tougher penalties for major league players who violate the sport's drug agreement. (AP Photo/The Arizona Republic, Cheryl Evans) MARICOPA COUNTY OUT; MAGS OUT; NO SALES

SCOTTSDALE, Ariz. (AP) ? Baseball Commissioner Bud Selig called for tougher penalties for major leaguers who violate the sport's drug agreement, a move the union is willing to consider but not for the 2013 season.

Speaking at a news conference Saturday at the Arizona Diamondbacks' spring training ballpark, Selig said last year's positive drug test for All-Star game MVP Melky Cabrera and allegations players received banned substances from a now-closed Florida anti-aging clinic helped lead him to seek stiffer penalties as quickly as possible.

He declined to give specifics, saying MLB Executive Vice President Rob Manfred and players' union head Michael Weiner will meet.

Weiner said Monday that some players have expressed support for tougher penalties. Selig said he was encouraged by Weiner's comments.

"The players have been discussing whether changes in the penalties are warranted since the offseason," Weiner said Saturday during a telephone interview. "As I've said throughout spring training, there's a variety of player views on this subject. In fact, during the offseason we suggested to the commissioner's office the possibility of differential penalties, namely advanced penalties for certain intentional violations but reduced penalties for negligent violations.

"That format was not of interest to MLB at that time. We look forward to ongoing negotiations over the drug program, but any change in the penalties would be a 2014 issue. It would be unfair to change the drug-testing rules now that the 2013 program has begun to be implemented."

MLB and the union started urine testing with an anonymous survey in 2003 and added penalties in 2004, when a first offense resulted in treatment. A 10-day suspension for a first offense was instituted for 2005, and the current discipline structure has been in place since the 2006 season: 50 games for an initial PEDs infraction, 100 games for a second and a lifetime ban for a third. No player has reached the third level.

The initial penalty for a stimulants offense is follow-up testing, with a 25-game penalty for a second violation, 80 games for a third and the discipline for additional offenses to be determined by the commissioner under a "just cause" standard.

Selig wants a tougher penalty for first-time offenders.

"There's no question about that," he said.

Twelve players were given 10-day suspensions in 2005. Thirty suspensions have been announced from 2006 on, including just two 100-game bans ? to pitcher Guillermo Mota and catcher Eliezer Alfonzo. The penalty for Alfonzo was cut to 48 games because of procedural issues similar to the ones that led an arbitrator last year to overturn Ryan Braun's positive test for elevated testosterone before a suspension was announced.

Suspensions for positive urine samples announced in 2012 increased to eight, when Cabrera, Bartolo Colon and Yasmani Grandal all tested positive for testosterone.

"We've made meaningful adjustments to our testing, and the time has come to make meaningful adjustments to our penalties," Selig said. "There is no question that there have been enough events that say to me the program is good, but apparently the penalties haven't deterred some people."

Players and management added spring training blood testing for human growth hormone last year and in January announced a deal expanding it to the regular season. Also in January, they said the World Anti-Doping Agency laboratory in Laval, Quebec, will keep records of each player, including his baseline ratio of testosterone to epitestosterone. The lab will conduct Carbon Isotope Ratio Mass Spectrometry (IRMS) tests of any urine specimens that "vary materially."

MLB was the first major sports league in North America to test for HGH.

Selig said those who have violated the anti-drug rules are "a very small percentage" of players.

"A great majority really, really have been terrific," Selig said, "and I give the players' association a lot of credit. We had lots of problems two decades ago, 10 years ago, but I'm confident that Michael and Rob will sit down, because I feel very strongly about this."

Cabrera, who was leading the NL in hitting for the San Francisco Giants, was suspended for 50 games last year. After asking for a rules change that prevented him from winning the NL batting title, he signed a $16 million, two-year contract with Toronto during the offseason.

Selig would not comment on the now-defunct Biogenesis of America clinic in Coral Gables, Fla., other than to say it is the subject of a "very thorough investigation" by MLB.

The facility was alleged in media reports to have provided performance-enhancing substances to several players, including Cabrera, Alex Rodriguez and Nelson Cruz. The players have denied they obtained banned drugs from the clinic. MLB has been trying to obtain purported records of the clinic posted online by The Miami New Times, which initially revealed the allegations.

"The program is working fine," Selig said, "but I've come to the conclusion the more I've thought about this that obviously there are some people, small in number, who need to be given a tougher lesson."

In the year ending with the 2012 World Series, there were seven positives for performance-enhancing substances and 11 for stimulants among 3,955 urine tests and 1,181 blood tests, according to a report issued in November by baseball's independent program administrator, Dr. Jeffrey M. Anderson.

"We're way ahead of what anybody could have thought, but my father used to tell me life is nothing but a series of adjustments," Selig said, "and this is an adjustment that you have to make based on what you see."

Joe Torre and Tony La Russa, retired managers who work for Major League Baseball, both voiced support for the tougher penalties at Selig's news conference.

Torre, the former New York Yankees and Los Angeles Dodgers skipper who will manage the United States in the World Baseball Classic, said it is important to remove questions fans may have about whether players are clean.

"Until we can gain the total respect back from fans and have them trust us again, we've got work to do," he said.

La Russa, longtime manager of the St. Louis Cardinals, said although the punishment already is severe, it apparently isn't enough.

"Just make that risk so punishing that we can eliminate this," he said.

Selig said stiffer penalties are in the best interest of baseball.

"Anybody who will be dismayed by this announcement is living in a world that I don't understand," he said, "and in my own feeling frankly doesn't exist."

___

AP Sports Writer Ronald Blum in New York contributed to this report.

___

Follow Bob Baum at www.twitter.com/Thebaumerphx

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-02-BBO-Selig-Drugs/id-7f12f5dbe2fc4637acec7aa006c88cc5

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Crews end effort to find man in sinkhole

SEFFNER, Florida (Reuters) - Florida rescue workers have ended their efforts to recover the body of a man who disappeared into a sinkhole that swallowed his bedroom while he slept and will demolish the suburban Tampa home due to its dangerous conditions, an official said on Saturday.

Jeff Bush, a 36-year-old landscaper, is presumed dead after disappearing into the sinkhole that opened suddenly beneath his room on Thursday night. Five other people in the house were getting ready for bed when they heard a loud crash and Jeff screaming.

His brother had to be rescued after jumping into the hole and furiously digging in an effort to find him.

Authorities used listening devices and cameras at the scene of the 30-foot (9-meter) wide hole in the ground but detected no signs of life.

"There's nothing compatible with life in this situation," said Hillsborough County Fire Rescue spokeswoman Jessica Damico. "There's no way of possible survival."

She said demolition of the home would begin early on Sunday.

"Our data has come back, and there is absolutely no way we can do any kind of recovery without endangering lives of workers," she said.

Jeff Bush's brother, 35-year-old Jeremy Bush, feared earlier on Saturday that his brother was lost forever. A small memorial of balloons and flowers for Jeff Bush had formed near the home on Saturday morning.

"I thank the Lord for not taking my daughter and the rest of my family," said Jeremy, who worked with his brother in landscaping.

Jeremy himself was rescued from the sinkhole by the first responder to the emergency call, Douglas Duvall of the Hillsborough County Sheriff's Office. When Duvall entered Jeff Bush's bedroom, he saw a widening chasm but no sign of Jeff.

"The hole took the entire bedroom," said Duvall. "You could see the bedframe, the dresser, everything was sinking."

Norman Wicker, 48, the father of Jeremy's fianc?e who also lived in the house, said "it sounded like a car ran into the back of the house."

Damico said the hole would be stabilized after the home is demolished to ensure the safety of the surrounding area. However, the residents of two neighboring homes who were forced to evacuate are unlikely to be able to return, she said.

Soil samples showed the sinkhole had compromised the ground beneath the homes, engineers and public safety officials said on Saturday.

The residents of one house were allowed 20 minutes in their home on Saturday to gather belongings. Firefighters and residents formed an assembly line to move items out of the house and into SUVs and trucks.

"They'll most likely never be allowed back in their houses," Damico said.

The risk of sinkholes is common in Florida due to the state's porous geological bedrock, according to the Florida Department of Environmental Protection.

As rainwater filters down into the ground, it dissolves the rock, causing erosion that can lead to underground caverns, which cause sinkholes when they collapse.

(Additional reporting by Brendan O'Brien and Colleen Jenkins; Editing by Barbara Goldberg and Todd Eastham)

Source: http://news.yahoo.com/recovery-effort-ends-florida-man-presumed-dead-sinkhole-001123737.html

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The Simpsons Do the Harlem Shake!

Source: http://www.thehollywoodgossip.com/2013/03/the-simpsons-do-the-harlem-shake/

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Here's How We Go to Space Now

This morning, Elon Musk's SpaceX program shot its third rocket into space. The Falcon 9 carries with it a Dragon cargo capsule, and will deliver supplies to ISS astronauts not entirely unlike a 19th century freight train delivering mining equipment to California. The launch, as you can see in the video above, went off without a hitch. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/BIWXvdqvtIg/heres-how-we-go-to-space-now

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Jennifer Lawrence: No Makeup! Brown Hair! [Photos]

Source: http://www.thehollywoodgossip.com/2013/02/jennifer-lawrence-no-makeup-brown-hair-photos/

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State Department Finds No Major Objections To Keystone XL Pipeline Proposal

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Source: http://www.npr.org/2013/03/01/173271257/state-department-finds-no-major-objections-to-keystone-xl-pipeline-proposal?ft=1&f=1007

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Announcing the Insert Coin: New Challengers finalists!

Hard to believe, but March is here, and with this lambing-lion of a month comes Engadget's first-ever Expand conference in San Francisco. It also marks the impending culmination of our first-ever Insert Coin: New Challengers competition. Late last year, we asked makers to submit their projects for a chance to win $25,000 in prizes. We whittled that list down to 10 semifinalists and asked you to help up get it down to a final five, which will go up in front of our all-star panel of judges on March 16th and 17th. Finalist voting closed yesterday, and we've tallied the 5 projects that will be demoed on stage. Check them out after the break, and be sure to follow our coverage at Expand for a chance to help pick the Grand Prize and People's Choice winners.

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Source: http://www.engadget.com/2013/03/01/insert-coin-finalists/

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